The neural ELAVL protein HuB enhances endogenous proto-oncogene activation

Role of proto-oncogene activation in carcinogenesis.

The accumulation of genetic damage in the forms of activated proto-oncogenes and inactivated tumor-suppressor genes is the driving force in the evolution of a normal cell to a malignant cell. For example, both the activation of ras oncogenes and the inactivation of several suppressor genes, including p53, have been observed in the development of human colon and lung tumors. Point mutations in k...

Sperm-egg binding protein or proto-oncogene?

Sperm - Egg Binding Protein or Proto - Oncogene ?

tized. The hybridization signal of the radiolabeled probe appears as white grains. All specimens were observed under dark field illumination after nuclear counterstain with hematoxylin. Immunostaining for factor Vill-related antigen (4) confirmed that injury was limited to endothelium. 23. Binding was carred out in buffer containing 50 mM NaCI, 5 mM MgCI2, 5% glycerol, 2.5 mM Hepes (pH 7.9), 1 ...

The protein encoded by the human proto-oncogene c-myc.

The proto-oncogene c-myc may play a role in controlling the growth and division of normal cells, and abnormalities of the gene have been implicated in the genesis of a substantial variety of human tumors. To facilitate further study of these issues, we developed antisera that permit the identification and isolation of the protein encoded by the human and other mammalian versions of c-myc. We fo...

RET Proto-Oncogene

Hereditary medullary thyroid carcinoma (MTC) is caused by autosomal dominant gain-of-function mutations in the RET proto-oncogene. Associations between specific RET mutations (genotype) and the aggressiveness of MTC and presence or absence of other endocrine neoplasms (phenotype) are well documented. Mutations in six exons (10, 11, 13, 14, 15, and 16) located in either cysteine-rich or tyrosine...